PK/PD and QSP Modeler, Neuroscience - Senior Scientist, DMPK & Modeling
Company: Takeda Pharmaceutical
Location: Boston
Posted on: October 23, 2024
Job Description:
By clicking the "Apply" button, I understand that my employment
application process with Takeda will commence and that the
information I provide in my application will be processed in line
with Takeda's and . I further attest that all information I submit
in my employment application is true to the best of my
knowledge.Job DescriptionAbout the role:At Takeda, we are a
forward-looking, world-class R&D organization that unlocks
innovation and delivers transformative therapies to patients. By
focusing R&D efforts on three therapeutic areas and other
targeted investments, we push the boundaries of what is possible in
order to bring life-changing therapies to patients worldwide.Are
you looking for a patient-focused, innovation-driven company that
will inspire you and empower you to shine? Join us as a PK/PD and
QSP modeler, Neuroscience - Senior Scientist in our Cambridge, MA
location.Objective / Purpose:As a PK/PD and QSP modeler,
Neuroscience - Senior Scientist in DMPK & Modeling, you will be
empowered to interface between biology/pharmacology,
chemistry/biologics, nonclinical safety assessment, drug
metabolism, translational medicine, clinical pharmacology and
clinical research, to influence drug discovery and development.How
you will contribute:ACCOUNTABILITIES -
- Drive decision-making in drug discovery research by building a
quantitative model of novel therapeutic agents to treat various
neurological diseases including neurodegeneration and neuromuscular
diseases.
- Work on cross-functional teams with preclinical
biology/pharmacology, chemistry/biologics, nonclinical safety
assessment, translational medicine, clinical pharmacology and
clinical research to develop a quantitative model-based
understanding of the interactions of target biological pathways and
novel therapeutic agents, and their impact on disease
progression.
- Formulate and implement team-engaged right modeling &
simulation strategy. Design and build translational PK/PD/efficacy
and mechanistic and/or systems models to assist and accelerate
decisions around drug candidate selection, study design
optimization as well as biomarker selection.
- Enable translational predictions of human pharmacologically
active/efficacious dose, dosing schedule and safety margin for
clinical trials. Leverage clinical benchmarking insights from
clinical comparators and/or their reverse translation.Minimum
Requirements/Qualifications:
- MS/PhD/PharmD in chemical or biomedical engineering,
pharmaceutical sciences, mathematics, physics, or equivalent
area.
- Strong competency in building mathematical models is required
(in commonly used languages such as MATLAB, SimBiology, NONMEM,
Phoenix, Python, or R)
- At least 2 years (8 years with MS) of industry experience in
mathematical modeling of biological systems.
- Demonstrated strong analytical skills to evaluate complex
information and identify key scientific questions.
- Ability to communicate complex modeling results clearly and
concisely to cross-functional audience is critical.
- Background or interest in applying modeling and simulation
approaches to neurological diseases is preferred.This position is
currently classified as "hybrid" in accordance with Takeda's Hybrid
and Remote Work policy.Takeda Compensation and Benefits SummaryWe
understand compensation is an important factor as you consider the
next step in your career. We are committed to equitable pay for all
employees, and we strive to be more transparent with our pay
practices. -For Location:Boston, MAU.S. Base Salary
Range:$133,000.00 - $209,000.00The estimated salary range reflects
an anticipated range for this position. The actual base salary
offered may depend on a variety of factors, including the
qualifications of the individual applicant for the position, years
of relevant experience, specific and unique skills, level of
education attained, certifications or other professional licenses
held, and the location in which the applicant lives and/or from
which they will be performing the job.---The actual base salary
offered will be in accordance with state or local minimum wage
requirements for the job location. -U.S. based employees may be
eligible for short-term and/ or long-term incentives. U.S. based
employees may be eligible to participate in medical, dental, vision
insurance, a 401(k) plan and company match, short-term and
long-term disability coverage, basic life insurance, a tuition
reimbursement program, paid volunteer time off, company holidays,
and well-being benefits, among others. U.S. based employees are
also eligible to receive, per calendar year, up to 80 hours of sick
time, and new hires are eligible to accrue up to 120 hours of paid
vacation. -EEO StatementTakeda is proud in its commitment to
creating a diverse workforce and providing equal employment
opportunities to all employees and applicants for employment
without regard to race, color, religion, sex, sexual orientation,
gender identity, gender expression, parental status, national
origin, age, disability, citizenship status, genetic information or
characteristics, marital status, status as a Vietnam era veteran,
special disabled veteran, or other protected veteran in accordance
with applicable federal, state and local laws, and any other
characteristic protected by law.LocationsBoston, MAWorker
TypeEmployeeWorker Sub-TypeRegularTime TypeFull time
Keywords: Takeda Pharmaceutical, Peabody , PK/PD and QSP Modeler, Neuroscience - Senior Scientist, DMPK & Modeling, Other , Boston, Massachusetts
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